Autism

Of course, both disorders are not a disease; so it cannot be cured but….

Telomerase EPINATIV

Germany, Thailand, Bangladesh, South Korea, Vietnam, Taiwan
Prof. Dr. Michael W. Trogisch
CEO and Founder

Diseases, environmental factors and eating habits in- fluence our quality of life and reduce our general life expectancy. Scientific research projects and studies have put the focus of interest on how our chromosomes function. The “building blocks of life” give important instructions to our bodies about development, growth and basic functions. Telomeres The end of a chromosome is known as a telomere. They act as a “protective cap”. Telomeres protect the chromosomes from degradation and ensure the proper functionality and viability of cells. However, during the course of our lives, these telomeres become shorter.

The decisive factors are genetic disposition and lifestyle. Obesity, smoking, mental stress and inflammations contribute significantly to the abrasion and shortening of telomeres. Factors such as healthy eating, sufficient sleep and exercise have a positive effect against this and provide a protective function, thereby leading to biological rejuvenation.

If the telomeres become too short, the cells cannot replicate any longer. The telomeres shorten gradually as they age, therefore, the ability of stem cells to generate tissue is impaired. This leads to ageing and disease processes. In particular, mental performance declines significantly and a once-intact immune system function less and less efficiently. The condition of the telomere is strongly linked with cardiovascular diseases, dementia, depression, diabetes, infertility and cancer. In a large number of scientific studies in the USA, the causes and effects of the shortening of telomeres have been examined and a Nobel prize has even been given in this area of research. The length of the telomeres can be determined by analytical methods in laboratories.

Telomerase

The enzyme telomerase is able to repair short telomeres by lengthening them. Unfortunately, healthy cells do not normally produce a lot of telomerases, if at all. However, some stem cells do produce this enzyme. In particular, you can find it in embryonic stem cells (or iPSC).

Through the specific protein chain EPINATIV, made of the amino acids alanine, glutamine, asparagine and glycine (ALA-GLU-ASP-GLY), the activation of the enzyme telomerase can be triggered in the body. The structure of EPINATIV is identical to that of the body’s own Epithalamine.

EPINATIV intervenes to regulate the hormonal balance in the human body and optimizes hormonal growth and ageing processes, as well as stress influences and cellular oxidation processes.
Epinativ:…

• activates the enzyme telomerase and lengthens the telomeres
• increases sensitivity of the hypothalamus for hormonal effects
• inhibits spontaneous and induced carcinogenesis (generation of tumors)
• normalizes the immune function of T cells
• normalizes the electrolyte balance in the metabolism and circulation
• normalizes the cholesterol level
• normalizes the uric acid level
• normalizes the level of gonadotropin hormones (e.g. prolactin)
• positive impact on hemodynamics, which means improved blood flow and blood supply in the body’s vascular system
• regulates the compounds affected by acute inflammation processes
• regulates the neuroendocrine system
• strengthens and rejuvenates the entire immune system

Epitalon

Epithalamine is a peptide that regulates the progression of the cell life cycle by increasing the activity of the enzyme telomerase and intervening in hormonal regulation mechanisms. It appears naturally in the human body and is produced in the pineal gland inside the brain. Unfortunately, not in a sufficient amount. One of its most important tasks is the regulation of the metabolism by the pineal gland (which produces the chronobiologically regulating hormone melatonin), the elevation of hypothalamus sensitivity, the normalization of hormone. response capacity of the anterior pituitary (the most important part of the pituitary gland) and the regulation of the levels of gonadotropin (sexual hormone that stimulates the gonads) and melatonin in the body.

Epitalon appears to induce telomere elongation via increased telomerase activity in human somatic cells in vitro, based on a study in human fibroblast cell cultures. Elongation of telomeres by epitalon was sufficient to surpass the Hayflick limit in a cell culture of human fetal fibroblast cells, extending their proliferative potential from termination at the 34th passage in the control cell population to beyond the 44th passage in the treated cell population, while increasing the lengths of their telomeres to levels comparable to those of cells in the original culture.

Epitalon induces decondensation of heterochromatin near the centromeres in cultured lymphocytes originating from samples taken from humans of ages 76 to 80 years.

Epitalon appears to inhibit the synthesis of the MMP9 protein in vitro in aging skin fibroblasts.

In human clinical studies, epitalon and epithalamin both significantly increased telomere lengths in the blood cells of patients of ages 60-65 and 75-80, and their efficacy was comparable to one another.

Epitalon and epithalamin appear to restore melatonin secretion by the pineal gland in aged humans.

A human clinical trial conducted on a sample of retinitis pigmentosa patients found that epitalon produced a positive clinical effect in 90% of cases in the treated group.

In another human clinical trial conducted on a sample of pulmonary tuberculosis patients, epitalon did not appear to correct pre-existing structural aberrations of chromosomes associated with telomere degradation, but did appear to exert a protective effect against the future development of additional chromosomal aberrations.

A human prospective cohort study conducted on a sample of 266 people over age 60 demonstrated that treatment with epithalamin, the pineal gland extract upon which epitalon is based, produced a 1.6–1.8-fold reduction in mortality during the following 6 years, a 2.5-fold reduction in mortality when combined with thymulin, and a 4.1-fold reduction in mortality when combined with thymulin and administered annually instead of only once at study onset.

Another prospective cohort study on a sample of 79 coronary patients spanning in excess of 12 years found improved metrics of physical endurance, circadian rhythm, and carbohydrate and lipid metabolism in the treated group relative to the control group following 3 years of biannual epithalamin treatments, as well as a 50% lower rate of cardiovascular mortality, a 50% lower rate of cardiovascular failure and serious respiratory disease, and a 28% lower rate of overall mortality.